Bedaquiline: A novel drug to combat multiple drug-resistant tuberculosis
نویسندگان
چکیده
منابع مشابه
Extensively drug-resistant tuberculosis: early access to bedaquiline for a UK patient.
5 Sotgiu G, Centis R, D’Ambrosio L, et al. Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis. Eur Respir J 2012; 40: 1430–1442. 6 Migliori GB, Sotgiu G. Treatment of tuberculosis: have we turned the corner? Lancet 2012; 380: 955–957. 7 De Lorenzo S, Alffenaar JW, Sotgiu G, et al. Efficacy and safety of meropenem...
متن کاملA Review of the Evidence for Using Bedaquiline (TMC207) to Treat Multi-Drug Resistant Tuberculosis
Existing therapies for multi-drug resistant tuberculosis (MDR-TB) have substantial limitations, in terms of their effectiveness, side-effect profile, and complexity of administration. Bedaquiline is a novel diarylquinoline antibiotic that has recently been investigated as an adjunct to existing therapies for MDR-TB. Currently, limited clinical data are available to evaluate the drug's safety an...
متن کاملClinical access to Bedaquiline Programme for the treatment of drug-resistant tuberculosis.
While clinical disease caused by drug-sensitive Mycobacterium tuberculosis (MTB) can usually be treated successfully, clinical disease caused by drug-insensitive MTB is associated with a poorer prognosis. In December 2012, a new drug, bedaquiline, was approved by the US Food and Drug Administration. This article documents the process whereby the National Department of Health, Right to Care and ...
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The new drugs delamanid and bedaquiline are increasingly being used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB). The World Health Organization, based on lack of evidence, recommends their use under specific conditions and not in combination. No systematic review has yet evaluated the efficacy, safety, and tolerability of delamanid and bedaquiline use...
متن کاملextensively drug-resistant tuberculosis: a review article
extensively drug-resistant tuberculosis (xdr-tb) is a new challenge for tuberculosis control programs. lack of effective drugs and high rate of failure in treatment and mortality is a major threat for public health. treatment of this serious infection needs well-designed individualized dosage regimen and powerful national tb program. in this review we will describe the xdr-tb definition and its...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Pharmacotherapeutics
سال: 2014
ISSN: 0976-500X
DOI: 10.4103/0976-500x.124435